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Methylfolate PlusTM and 5-MTHF Plus ForteTM

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Methylfolate PlusTM and 5-MTHF Plus ForteTM supplies
folate, in the active form of (6S)-5-Methyltetrahydrofolic acid, glucosamine salt. Methylfolate is a highly absorbable, activated form of folate, which does not require enzymatic conversion to
5-methylfolate in the body. The glucosamine salt form utilized in Methylfolate PlusTM and 5-MTHF Plus ForteTM is more stable than other forms of methylfolate often used.

While a small percentage of the general population (≤ 10%) lack the enzyme (methylentetra-hydrofolate reductase) needed to convert folic acid due to a genetic defect (homozygous TT), a larger percentage (heterozygous CT) are suspected to convert a limited amount of

folic acid.

 Folate de ciency is one of the most common vitamin de ciencies.In individuals with homozygous (TT) or heterozygous (CT) genetic predisposition, eating folate-rich foods may not provide the recommended daily dosage of folate; thus the need for supplementation. By providing 5-methylfolate directly, Methylfolate PlusTM and 5-MTHF Plus ForteTM may have bene ts for those who do not produce enough 5-methylfolate in response to folic acid supplementation.

Each serving (1⁄2 tablet) of Methylfolate PlusTMsupplies 400 mcg of folate as 5-methylfolate combined with 25 mcg of vitamin B12 as methylcobalamin in our biologically active, phytochemically rich vegetable culture base.

Each serving (1⁄2 tablet) of 5-MTHF Plus ForteTM supplies 2,500 mcg of folate as 5-methylfolate combined with 25 mcg of vitamin B12 as methylcobalamin in our biologically active, phytochemically rich vegetable culture base.

These statements have not been evaluated by the Food and Drug Administration. 


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